プロセス化学アプリケーションノート

Jäkel and Paciello (BASF) describe various literature references to the usage of the Endeavor catalyst screening system for use in screening of catalyst for asymmetric hydrogenation applications.

Describes how the Advantage Series™ 3400 ChemCorder™ workflow replicator was utilized to record the manual operations a chemist performs during a highly exothermic chemical reaction.

Describes how the Advantage Series™ 3400 heat flow parameter can be used to monitor the progress of a reaction, and can be useful in determining reaction rates.

This application note describes how the synthesis and workup were screened and optimized utilizing parallel synthesis on the Advantage Series™ 2050 manual chemistry synthesizer and further characterized on the 3400 process chemistry workstation.

This case study details how the unique temperature based feed mode of reagent addition for the Advantage Series 4100 process scale-up reactor was utilized to by the Discovery Process Research (DPR) group at Dow AgroSciences to quickly scale-up a compound.

This case study details how the Advantage Series 4100 process scale-up reactor interfaces with third party analytical devices. Utilizing data from analytical devices to make step termination decisions, the Advantage Series 4100 allows for much faster and more accurate metastable zone width crystallization studies.

The removal of colored impurities (De-colorization) from natural products, organic and inorganic compounds at bench scale and industrial scale is commonly accomplished via batch charcoal absorption techniques. The de-colorization procedure can be more efficient, faster and easier using a pre-packed charcoal cartridge.

This paper demonstrates the variables to optimize a successful cartridge decolorization step using a synthetic mixture of phenol and methyl red. This paper also compares the decolorization results from a batch process and prepacked cartridge process.

The variables to remove color using the FLASH-AC cartridges are discussed in the application note #12 titled Decolorization of Products with FLASH-AC. In this work these principles are applied decolorizing an organic synthesis intermediate. Removing the degradation products from an intermediate product is desirable to minimize the impurities formed in subsequent synthetic steps.

Purifying the reagents before synthesis significantly improves the color and purity of the final product. In practical applications the purification of a degraded reagent before synthesis will reduce or eliminate purification of the final product. Purification before the synthesis step prevents process losses of the final product. This process is ideal for degradable reagents since purification can be performed immediately before the synthesis.

The value of many harvested, plant-based compounds is negatively affected by the presence of highly colored tannins. Tannins are a series of polyphenol components that are traditionally removed by adsorption onto activated carbon, but this process using loose carbon media is awkward, especially in a cGMP environment.

Adsorbent media efficiency is most effective when packed into cartridges. The particle size of the packed media affects cartridge performance. Packed cartridges containing granular carbon, powdered carbon, and conditioned carbon were evaluated for performance when packed into identical cartridges.